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Category: Biotechnology/Pharmaceutical
Title: Director of Molecular Biology
Description: The Director of Molecular Biology will be responsible for all aspects of Company's display-based platform for identifying therapeutically relevant leads. They will generate large libraries of proteases, and utilize Company's proprietary selection technology, as well as work with the automation team to develop and utilize screens for characterizing hits. The department will also support the general molecular biology needs of Company. In addition to their own hands-on efforts, the Director will oversee the efforts of two Ph.D. level scientists, as well as manage internal and external cross-functional resources.
Qualification: Requirements: -PhD in molecular biology, biochemistry or relevant fields. -5-10 years of experience following post-doctoral studies -Extensive and in-depth experience in phage, phagemid, etc. library design, construction, selection and screening. -Experience in updated methods for rapid cloning and small scale expression. -In depth experience with up-to-date molecular biology techniques and protocols -Comfortable working in a fast-paced, innovative environment Preferred Experience: -industrial experience, and/or experience in a drug-discovery environment. -experience will other forms of "molecular evolution" or protein maturation -familiarity with protein engineering and/or protease biochemistry. -experience in evolution of catalytic antibodies -familiarity with key bioinformatics tools.
Contact: philp@nsasearch.com
Category: Biotechnology/Pharmaceutical
Title: Research Fellow, Toxicology
Description: KEY RESPONSIBILITIES -Partner with the Sr. Director of Development and work with outside experts to develop nonclinical strategies for company's drug discovery pipeline. -Develop plans for conducting safety pharmacology and exploratory toxicology studies and studies to support regulatory submissions: identify contract labs for conducting the studies, generate protocols and closely support/monitor the conduct of these studies. -Provide analysis and interpretation of data and preparation for final reports, critically review and edit study reports. -Assume team representation at project teams. Design and support project related in-house experiments with expertise and experience. -Identify and apply novel technology and expertise to enhance drug discovery research programs. -Respond quickly to information learned from ongoing studies and provide input to drug discovery and development management to guide program direction and prioritization. -Work with CMC team to ensure supply of appropriate nonclinical test materials. -Generate/review regulatory documents for pre-IND packages and IND submissions and Investigators' brochures -May interact with FDA on nonclinical matters.
Qualification: QUALIFICATIONS · Ph.D. degree; Board Certification in Toxicology desired· 5+ years experience in nonclinical pharmaceutical drug development, with a primary focus, for 2+ years, in toxicology · Experience in toxicology/pharmacology related to all stages of drug development from feasibility to regulatory submissions · Experience and responsibility in preparing at least one IND · Experience in working with contract labs and outstanding relationships with lab study directors · Experience in FDA interactions · Experience in safety pharmacology (desirable but not required)
Contact: philp@nsasearch.com
Category: Biotechnology/Pharmaceutical
Title: Director, Neurodegenerative Bi
Description: The successful candidate will be a Neuroscientist/Molecular Pharmacologist who will craft, implement, and manage three to four independent drug discovery campaigns from Lead Generation through Candidate Selection. The position involves collaborating with a small group of scientists on-site and a much larger "virtual" team of external collaborators, including academic and industrial scientists, to discover and develop therapies for Huntington disease.
Qualification: The responsibilities include: -Work closely with academic and industrial collaborators to acquire, validate, and integrate the needed in vitro and in vivo assays. -Identify and establish new collaborations with academic and industrial organizations to provided needed services. -Devising predictive flow schemes for each nominated target/campaign. -Achieve milestone based goals to rapidly identify clinical candidates. -Partner with the chemistry staff to evaluate the progression of compounds through the pipeline. -Work with down-stream scientists to incorporate needed pre-clinical and clinical requirements. Requirements: The candidate of choice should have: -A PhD in Neuroscience, Pharmacology, Cell Biology or Biochemistry. -7-10 years of experience in the biopharmaceutical sector within CNS drug discovery -A detailed theoretical and practical knowledge of neuroscience, neurodegeneration and pharmacology. -Proven track record developing phenotypic and/or target-based HTSs for multiple target classes. -Demonstrated track record of leading drug discovery project teams. -Significant experience leading targets & projects through sanctioning milestones, e.g., lead declaration, pre-clinical candidate selection. -Background in neuropathology studies -Demonstrated track record of effectively supporting Medicinal Chemistry teams
Contact: philp@nsasearch.com
Category: Biotechnology/Pharmaceutical
Title: Principal Scientist: Oncology
Description: -Design, develop, and validate relevant in vivo oncology related models for solid tumor (subcutaneous) and hematologic malignancies -Establish innovative pharmacodynamic and tumor models -Contribute to the development of new disease models, explore disease mechanisms and mechanisms of drug action in vivo and provide in vivo proof of concept for novel therapeutic targets -Assume team member representation at project teams. Candidate will actively participate in both departmental and cross-departmental interactions -Deliver in vivo models and studies to facilitate selection of disease settings, discovery and validation of biomarkers -Plan, implement and manage internal and external in vivo pre-clinical activities and interactions to deliver key experimental studies to support drug candidates in discovery research -Present results both written and verbal and deliver completed reports within a multidisciplinary team environment. -Key responsibilities include compound formulation, preliminary safety assessment and assessments of efficacy and PK/PD for drug candidates tested alone or in combinations. He/She will closely collaborate/i9nteract with other scientists from Leads Discovery Biology, Medicinal Chemistry, Structural Biology and Analytical Chemistry.
Qualification: -Ph.D. in Pharmacology or a related biological field with expertise in in vivo physiology or pharmacology -5+ years experience in oncology research in industry/biotech -Clear understanding of the integration of in vivo models into drug discovery programs -Broad experience in utilizing different in vivo models to include xenograft models and genetic approaches including genetically engineered mouse models -Proven record on scientific writing with publications in scientific peer-reviewed journals -Experience managing junior scientists -Experience with managing external activities through academic collaborations and CRO's -The candidate should have a comprehensive, in-depth knowledge of oncology research, particularly related to industrial drug discovery and development
Contact: philp@nsasearch.com
Category: Biotechnology/Pharmaceutical
Title: Manufcturi Suprvisor Upstream
Description: We are currently looking for a Manufacturing Supervisor for the Mammalian Upstream group in the Manufacturing Facility. Responsibilities include: • Ensure a high level of compliance with cGMP and other regulatory requirements such as validation and BLA commitments. • Collaborate on department, site and corporate teams and initiatives. • Assess daily shift needs and deploy staff accordingly. • Draft, review and approve manufacturing procedures and SOPs. • Write and review deviations and corrective actions • Assess staff performance, write and administer performance evaluations. • Follow and update production schedule as required. • Ensure assigned personnel are trained. • Ensure a safe work environment is maintained at all times.
Qualification: BS/MS degree in Science or Engineering and/or equivalent experience. • 4-6 years pharmaceutical or biotechnology (cGMP environment) experience. • Demonstrated subject matter expertise in at least one of the following areas: cell culture, fermentation, purification, and/or media/buffer supply systems. • Basic to advanced working knowledge of biotechnology/pharmaceutical production systems. • Ability to support and/or lead system troubleshooting efforts. • Ability to assist with on-going production issues such as investigations, optimization efforts and scheduling/logistical issues. • Excellent communication, analytical, and organizational skills. • Must have experience writing and reviewing process documentation batch records, standard operating procedures, protocols and reports. • Strong team player with the ability to supervise manufacturing associates. • Ability to recruit, hire and retain a motivated and effective team. • Ability to work a shift that covers a 24/7 operation.
Contact: franks@nsasearch.com
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Biotech & Pharmaceuticals